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However, scientists have pointed out that phytoestrogens probably have different effects in carnivores, such as cheetahs, compared to omnivores, like humans. When it comes to men’s health, scientists are most concerned that excessive exposure to phytoestrogens may reduce male fertility. However, there’s not much evidence that phytoestrogens have harmful effects in humans (20).
You can also schedule an appointment with a specialist today to discuss getting your levels tested. If you suspect sensitivity to certain foods, keep a simple food journal noting what you eat and how you feel for a few weeks. Instead of relying heavily on any single food source, aim for variety in your diet.
The anti-estrogenic activity of phytoestrogens is due to their structural similarity with 17-β-estradiol (E2), the main female sex hormone . Thus, due to their antioxidant, antiproliferative, antimutagenic, and antiangiogenic roles, phytoestrogens can improve health . Summary of potential health outcomes of phytoestrogens through the modulation of the endocrine system in (a) thyroids, (b) liver, (c) ovaries, (d) bones, (e) hypothalamic–pituitary–gonadal axis, (f) pancreas, (g) fat tissue, (h) prostate. However, some authors describe phytoestrogens as endocrine disruptors and believe their beneficial effects have been overestimated 2,5,7. In premenopausal and postmenopausal women, the reported impacts on hormones are inconsistent, although beneficial goitrogenic effects and improved glycemic control and cardiovascular risk markers have been described in postmenopausal individuals. Evidence from preclinical studies suggests these compounds may have an effect on hormones and health, although the results of human trials are unclear.
In 2018, a study on protein supplements showed that soy had no effect on testosterone levels in males. A 2020 narrative review notes that topical phytoestrogens may be a promising treatment. A 2022 study evaluated the effects of giving 40 mg of soy isoflavones twice daily for 12 weeks to perimenopausal and postmenopausal females. Researchers are still learning about what the benefits of phytoestrogens may be. To a lesser extent, many other nuts and seeds also contain phytoestrogens, including peanuts and sunflower seeds. Unprocessed soybeans are high in the most well-studied phytoestrogen, isoflavones.
Several studies have suggested that high intake of phytoestrogens, particularly isoflavones from soy products, might result in a reduction in testosterone levels. Many men worry about whether certain types of foods—specifically those that contain phytoestrogens, like soy—might affect their hormone levels, particularly testosterone. Controversial results have been obtained by studies in healthy humans, who did not experience anti-thyroid or any other effects after consuming dietary phytoestrogens, particularly isoflavones. Several observational studies have found a negative association between the consumption of phytoestrogens (soy and its isoflavones) and the levels of prostate-specific antigen (PSA) in blood .
In comparison to the amount of estrogen the body naturally produces, the intake from everyday foods is usually very small. The overwhelming scientific consensus is that moderate soy consumption does not negatively impact male fertility or hormone levels. However, research generally shows that moderate soy consumption does not negatively affect testosterone levels or sperm count in men. The body’s normal endocrine functioning involves very small changes in hormone levels, yet we know even these small changes can cause significant developmental and biological effects. The human body is dependent on hormones for a healthy endocrine system, which controls many biological processes like normal growth, fertility, and reproduction. If you are concerned about phytoestrogens, consider choosing nuts with lower phytoestrogen content, such as macadamia nuts, cashews, or Brazil nuts.
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